Methadone Pregnancy Information / Methadone Pregnancy Info & Discussion / Archives / 08-25-2009 / Study- Phenobarbital use (along with an opioid) in treatment for NAS

Topie: Study- Phenobarbital use (along with an opioid) in treatment for NAS
June 9th, 2009 01:40 PM
Sharon Coyle MG; Ferguson A; Lagasse L; Oh W; Lester B. Diluted tincture of opium (DTO) and phenobarbital versus DTO alone for neonatal opiate withdrawal in term infants. Journal of Pediatrics 140(5): 561-564, 2002. (14 refs.)
Objective: The purpose of this study was to test the hypothesis that treatment of neonatal opiate withdrawal (NOW) in the term infant with diluted tincture of opium (DTO) and phenobarbital was superior to treatment with DTO alone. Study design: This was a partially randomized, controlled trial in which 20 term infants exposed to methadone and/or heroin in utero were studied. The severity, of NOW was assessed by using the Finnegan scoring system. Infants were assigned to either DTO and placebo (n = 10) or DTO and phenobarbital (n = 10) when medication was required. The primary outcome variable was the duration of hospitalization. Severity of withdrawal and hospital cost were secondary outcome variables. Results: There were no significant differences in the gestational age, growth variables, maternal methadone dose, or age at enrollment between the 2 groups. The duration of hospitalization was reduced by 48% (79-38 days) (P <.001) and hospital cost per patient reduced by $35,856 (P <.001) for the DTO and phenobarbital group. Furthermore, these infants spent less time, with severe withdrawal (P <.04), more time with mild withdrawal (P <.03), and required a lower maximum daily DTO dose (P <.009), when compared with the DTO-only group. The average duration of outpatient phenobarbital use, was 3.5 months. Conclusions: The combined use of DTO and phenobarbital resulted in a shorter duration of hospitalization, less severe withdrawal, and reduced hospital cost. This combination may be a preferred regimen for the treatment of NOW.
Copyright 2002, Mosby-Year Book, Inc.
June 10th, 2009 09:42 PM
Bella81 errrrrrrrrrr!! lol!!!!!!
June 10th, 2009 09:47 PM
grace131621 Too bad the hospital my son is staying at claims Phenobarb is useless for NAS. Go figure. They scared my boyfriend big time telling him our son would end developmentally delayed if treated with Phenobarb. No matter how much I begged for them to put him on it, they wont. Oh well, I did my best.
June 11th, 2009 08:44 AM
Sharon Grace,
At least print the articles and give them to the docs there. They need to update themselves and stop misinforming people!

Good luck honey!!

June 11th, 2009 11:46 PM
Bella81 i hope you let your man read this! its just making me so sick that these drs are so miss informed and making other people think the same!!! definitly give this to the dr!! he, they, all of them need to know!
June 12th, 2009 01:58 PM
Jessica1381 Grace, Sharon and Bella had a great idea to copy this aricle and give it to that doctor! He needs to read it! :) Jessica
June 12th, 2009 02:11 PM
Divinity- I soo agree Its deff hella important to let them see this