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faith
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Posts: 1250
Registered: Mar 2005
 Posted July 21st, 2006 01:02 PM   IP           Reply with quote Edit Post Delete post
Well according to studies that is a fact..Grapefruit and grapefruit juice does have an interaction with many drugs..in fact there has been some deaths caused by this interaction.

So as I have said before I have weekly takehomes. I find that my dose holds me nicely for the first 4 or 5 days of the week...than on the 6th and 7th day I feel yucky...like the dose is lessened somehow!

I really am starting to wonder if the stability of the methadone is affected by time..I mean I KNOW it is affected by time..a matter of I think a couple of months and it is no longer good...BUT when does it start to not be as good? On the 4th day sitting in my fridge mixed with the "tang"? That is what I think.

SO this last week the doses seemed to not be as strong on the last 2 days worth... and I do not take my bottles in order..I just grab any old one and drink it..as we are allowed to drink them in any order, we don't get what you call..uh.."Callbacks?" ya know when they call ya in and want to see your bottles?? This may be do to the fact that the longest we get is a weeks worth...( I am hoping that this is changing to two weeks.)

This may seem strange to you but I get this "funny tingle sound" in my head when a drug is working=king..it is sort of like a buzzing sound..I have known only a couple of people who have similar experience..like when I used to take morphine..which was rare for me..I used to get it..and I would only hear it until the drug would be wearing off...and The only 2 drugs I ever got it with was morphine and Methadone.. It is like..when I close my eyes and squeeze them shut I hear a "humming" or "buzzing" and it only happens when the drug is working..

Some times I have not taken my Methadone dose for a half day longer than my schedules dose time..and I still can hear that "buzz" but on the 7th day of my take home dose I can hardly hear that buzz...and I feel kind of crappy..

so this Thursday..was my pick -up day (as always) and the Wednesday night before I was working my graveyard shift as usual and feeling yucky when it struck me that the last day of my doses is always crappy..so I bought and drank up a small bottle of grapefruit juice..and I felt a bit better , as I got a bit of energy from the sugar..and that was all..SO I had to wait till I got off work..then I got home and finally 9:00 came and the drugstore opened so I got there in a cab and dosed..I also bought a bottle of Grapefruit juice..a large one..and came home..I drank 2 glasses of the juice right away...as I was feeling so yucky and headachy..

I have to tell ya..that my does that day seemed as if I had gotten an increase...I was much more relaxed and felt better.

So I then looked up in a search engine and found some article on the subject..and it turns out to be true that studies have shown it does affect the dose. BUT it also affect other drugs..like the Erythromycin which I am on also..so I skipped my dose for two doses as I didn't know how good it would be to mix them...now I am back to normal..

But I think that I will drink the juice on Wednesday after my dose ..to give it a boost..I mean even if it all "in my head" at least I will feel better..I just really think that after a week mixed with Tang sitting in the fridge the dose does get weakened..I feel it..so the juice can only help...and I am only taking it once a week...so..LOL me being an addict watch me OD on grapefruit juice..ha ha...I will be careful...just on Wednesdays...

So do you think that the juice makes a difff? I wonder if it is all in my head..I know the studies are there..but I don't know..I just drank red Grapefruit juice..as it doesn't matter what kind of grapefruit it is..any color is the same..

Love Faith




When you find yourself in the hole....stop digging.
   
danny
Posting Pro

Posts: 679
Registered: Apr 2006
 Posted July 22nd, 2006 12:43 PM   IP           Reply with quote Edit Post Delete post
I have read about this and it seems that some folks say it will increase the effects and some say it will not. I think I am gonna buy me some grapefruit juice and see if I can tell any difference. It would be cool if I could get the equivalent of a dose increase without having to ask for it.
May I be forever greatful, that at times, I didn't receive that which I truly deserved.

   
Marot
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Posts: 1218
Registered: Oct 2005
 Posted July 22nd, 2006 02:41 PM   IP           Reply with quote Edit Post Delete post
Grapefruit juice potentiates the Methadone, in other words it makes the effect stronger.....BUT this is because your body is processing it faster.....so you will get an increased effect of the Methadone......BUT it will wear off faster, and you will feel worse in the morning. Hope that answers the question.

Marot
   
Laura
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Posts: 320
Registered: May 2006
 Posted July 26th, 2006 11:22 PM   IP           Reply with quote Edit Post Delete post
ok i tried this as soon as i found out it would kick it in more and yes marot is right it makes it ware of much qicker so its up to you guys !!!!!!!LAURA
my life

   
Marot
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Posts: 1218
Registered: Oct 2005
 Posted July 27th, 2006 12:12 AM   IP           Reply with quote Edit Post Delete post
Yup Laura! It's the same with alcohol too! If Otto and I go out for dinner, and I have a few too many martinis, I find that I am a bit sick in the morning before my dose Kwim? So anything that would potentiate the Methadone, may be detrimental in the long run.

Love, Marot
   
faith
*MODERATOR*

Posts: 1250
Registered: Mar 2005
 Posted July 29th, 2006 07:02 AM   IP           Reply with quote Edit Post Delete post
You know..I am not sure what withdrawals from Methadone or opiates feels like...

But last week on a couple of mornings I felt a bit anxious and shaky and just yucky...so i would dose and then rest for a while and feel better..

This week i drank grapefruit juice for several days and I felt fine..the dose seemed just a wee bit stronger and didn't seem to last any less at all.. who knows maybe at the small amounts I used it doesnt do much of anything and it was all in my head...I drank a few cups each day with my dose..

SO much for that experiment lol

When you find yourself in the hole....stop digging.
   
ashley1978
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Posts: 827
Registered: Mar 2006
 Posted September 12th, 2006 02:54 AM   IP           Reply with quote Edit Post Delete post
Faith,

does your clinic, or pharmacy (I know youre in Canada, and I dont know HOW they do it there, Im sorry, like HERE we have the clinics, but in the UK they go to pharmacies to dose, so forgive me) but do they PREMIX your doses?? I saw you said after the 5-6th day you feel crappy and you credit this to it sitting in the fridge mixed with the "tang"??? Is there any way to NOT get in mixed, or just in water? My bottles say "140mgs mixed with 1 ml h2o" and I notice NO difference in the stregnth BUT I am asking because my clinic nurse (who is VERY knowledgeable and knows all the ins and outs, I mean REALLY, she is good) well she told me one day when we were talking about "what I take my dose with" and I told her I mix it with juice at home and she said "well do NOT mix it and let it sit, only mix the juice in when youre going to take it that day"....I dont go again this week til FRI so I cant ask her to elaborate, but I will....just something to think about??

Have you tried to look that up at all online? just cuz NOW I am curious lol!


Ash <3




   
ashley1978
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Posts: 827
Registered: Mar 2006
 Posted September 12th, 2006 02:58 AM   IP           Reply with quote Edit Post Delete post
also, MAROT: What about TAGAMENT? I have seen online that it has drug interactions with methadone and that it makes levels "higher", well I was sick of waiting 3 weeks for each increase at my clinic so about one month ago I started to take that, and I think it works. At least, I mean, I feel much more "stable" now than I did before....(I dont know if you remeber but I was having a hard time getting to a comfy level after my pregnancy, and my metabolism went back to normal) well as I said the clinic can literally take 3-4 weeks for ONE increase and I just was fed up, someone mentioned the "tagament" so I went and bought it, and have been better since about a week after I started taking it with the MMT....BUT if that does what the grapefriut does, well then, I dont wanna do THAT....so any info for me???



Ash <3




   
faith
*MODERATOR*

Posts: 1250
Registered: Mar 2005
 Posted October 30th, 2006 01:56 PM   IP           Reply with quote Edit Post Delete post
Hi ash 'bout time I answered this post huh? LOL I never read it till today actually, so I figure I might as well reply now...

As fer the Tagamat..yes it does have an interaction with the Methadone...and it makes it feel stronger and last longer..as it makes the levels higher. The same goes for the Grapefruit or grapefruit juice...
However the use of these things to increase the methadone's affects is much like reverting back to the addictive behavior we are trying to avoid..

i mean can you imagine being hooked on Tagamat to get your methadone to work well enough for you? Then you run out of tagamat and have no money and then what?? LOL Now you are going to be sick cause you're outa Tagamat...lol

Anyway, that sounds like a familiar pattern but it's usually with drugs not Tagamat and Juice..lol

As far as shelf life of the methadone, I did talk to the druggist and he said that it (mixed just with distilled water) is good for 3-6 months....and mixed with Tang it is only good for one month and has to be kept in the fridge..and it is the sugar in the tang that grows bacteria and the bacteria breaks down the Methadone and makes it less potent. So if kept out of the fridge it lasts even less time..

So it is completely fine for a month, which means that after a week it is fine..so when I got sick that day it might have been like the flu or maybe the dose was mistakenly less...

Who knows sometimes the druggists make mistakes and I betcha that sometimes I get higher dose, and other times i get less...I have felt that way a couple times anyhow...

As far as the Tang in the Methadone..they add it to the take homes to make it impossible to shoot...if they gave it without tang it can be used in a needle...

The sugars and powder in the Tang make shooting impossible...I saw this one lady's arm at the clinic one time and she said that she tried to shoot it the first take home she got..and it backfired on her...lol

Love Faith

When you find yourself in the hole....stop digging.
   
coppisc
Power Poster

Posts: 111
Registered: May 2006
 Posted November 3rd, 2006 03:30 PM   IP           Reply with quote Edit Post Delete post
Grapefruit has an enzyme in it that allows certain drugs and food to be completely absorb in your system (stomach by breaking it down) I have down countless hours of research on it, It is only found in pure non sugared grapefruit the yucky kind not the juicy in the convenienc store. Anyway back to what it does it metabolizes all of your methadone, your bpdy naturally cannot do this, it also works with some other drugs aswell
living IT ONE DAY AT A TIME IN SOUTH CAROLINA
   
faith
*MODERATOR*

Posts: 1250
Registered: Mar 2005
 Posted November 5th, 2006 10:22 PM   IP           Reply with quote Edit Post Delete post
WOw so that means the WHOLE amount of methaone gets broken down.?? Would that be sort of not safe..? Sounds bad...I mean it did cause a death with a woman I read about, she was on other medications though..not Methadone.

I do get the unsweetened kind from the grocery store sometimes..and it tastes yucky!! Anyways I try to stay away from that now, cause like someone else on here said it is too much like going back to addictive behavior..and besides if I need an increase I just have to ask...so what am I thinking?? LOL
And they give me the increase starting on the next pick up day..so I have No excuse...
Love Faith

When you find yourself in the hole....stop digging.
   
Melissa Wann
Unregistered

Posts: 1647
Registered: May 2006
 Posted November 6th, 2006 09:02 PM   IP           Reply with quote Edit Post Delete post
Hello everyone. Its about time I come and check out this Forum, It's so much more interesting over here, LOL!. About the grapefruit Juice thing....I have recently read, and spoken to my parmacisist about it, that grapefriut juice.... because of the acidity thats in it, it makes it pretty much bad to mix with any medications you are on. Especially methadone...I also know this because the nurses at my clinic always tell people NOT TO DRINK OR EAT GRAPEFRUIT ( Juice) while on the MMT program. All of my other meds usally all have the, "Caution: Do Not Drink or Eat Grapefruit " sticker on the sides of the pharmacy bottles too. I also know that EVERYONE'S Body is "totally diferent" than anothers body, so one person can have an increased Methadone level from it, and another person can have a decrease in their Meth. Level from it...just depends on the person, ya know? I am at the point in my life where I would rather be safe than sorry...and even though I absolutey LOVE & MISS my Grapefruit ( Pinks the best! Yummm!) I'd rather not risk anything. Well, thats my opinion. Good topics you all have on the forum Carol! I will be sure to come back more often...and thanks for everyone else sharing on this topic too!
Your sister in recovery...with Strength & Hope always....Melissa ( or just "Mel")
" I love nonsense, it makes the brain cells work"...~ By: Dr. Seuss

Sincerely,
Melissa Wann
Methadone Patient Advocate
Worldwide Rep. MA World Services
MA World Services Intergroup
http://www.MethadoneAnonymous.org/
www.MethadoneAnonymous.info
   
shelbs
Member

Posts: 51
Registered: Oct 2006
 Posted November 7th, 2006 02:16 AM   IP           Reply with quote Edit Post Delete post
I never thought of the grapefruit thing but that is interesting to know. My clinic doen't mix our methadone with anything. The one clinic I went to in the past use to mix it with tang. I guess I should stay away from grapefruit.
   
biscuit
Member

Posts: 53
Registered: Dec 2006
 Posted February 6th, 2007 09:55 AM   IP           Reply with quote Edit Post Delete post
grapefruit juice works well for for me with the methadone,to well i might add,i was scared as hell the day i did them together, i called mrmike on the phone and he calmed me down.i felt a huge increase from them,now i only take afew sips of the gr juice and that does the trick
   
Breeze
*MODERATOR*

Posts: 663
Registered: Dec 2006
 Posted February 6th, 2007 09:06 PM   IP           Reply with quote Edit Post Delete post
Actually, yes...a nurse that used to be at my clinic said they do NOT premix the methadone with anything, because some of us have monthlies, and it can ware on the methadone... And, they do not use tang. We pour our own water, if we want to, in our methadone dose as we take it. I just can't see how the tang would NOT interfere with the strength of the dose, especially doses that sit in the fridge for up to a month. It's very acidic isn't it? Weird. It's so funny, cuz I was thinking about this grapefruit thing for a couple of days. I was wondering if it made your dose stronger, or if it made it last longer. I just got an increase...worked great the first day, but I am right back where I was....instead of the detox symptoms starting at about 11am, they start at about 3pm... I think I need to go up again...but I am only going to go up 5mgs, instead of 10mgs. I want to do this slowly. I always always tell people not to look at the number of mgs, but listen to your body, and here I am not wanting to go up much higher. hehe What a hypocrite! hehe


Is peace too much to ask for?
   
faith
*MODERATOR*

Posts: 1250
Registered: Mar 2005
 Posted February 8th, 2007 11:59 AM   IP           Reply with quote Edit Post Delete post
Yes I just went to get my doses..and it is mixed with TANG!!! There is no way they will stop that..it is the rules...jerks..

They have said that it keeps some from poking it...so I mean yes I am sure some will do anything..but not me..they know that I have not abused any drug since I started the first day on Methadone!!

So when I was complaining about the TANG...the druggist explained to me..that is why they have a 30 day expirey on the methadone, it is becasue the Tang builds up more bacteria than just the Methadone...and the Bacteria breaks down the Methadone..which is why I am told to keep it in the fridge also..

The Methadone they give us here...if it was given without the TANG would have an expirey date of 3 months..as bacteria still does grow..but at a slower rate..

So I hope that if I get more take homes allowed...(the law here is still 2 weeks...crappy) like over 2 weeks..I will put up a fight against the TANG ...

The TAng really helps with the bitterness...as this stuff we get here is VERY bitter...makes even the tuffest tummy wanna hurl..

Love Faith

When you find yourself in the hole....stop digging.
   
Breeze
*MODERATOR*

Posts: 663
Registered: Dec 2006
 Posted February 8th, 2007 02:06 PM   IP           Reply with quote Edit Post Delete post
yeah...I don't understand why it's in the rules that the tang MUST be included. Gosh, I really do have a GREAT clinic. Some of the stories I here....gosh! i am NOT moving from AZ! hehe I love my clinic and owe all my success to the team at the clinic, as well as to myself. They have been hugely instrumental in my recovery!!! Like I mentioned above, yeah...we add our own water to our doses..no tang involved. I mean, if the tang really helps that much, well they should put out a pitcher with tang and a pitcher with water and leave that up to the patient's perefernces...I dunno....I've never had the tang, so i guess I don't have much to base my opinion off of...??
Is peace too much to ask for?
   



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Methadone Anonymous Forums :: REGULAR FORUMS :: BURNING QUESTION OF THE DAY :: Do u believe that Grapefruit juice can increase the affects of Methadone..or interact with drugs?
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